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Doublecortin-like kinase 1 activates NF-κB to induce inflammatory responses by binding directly to IKKβ
Doublecortin-like kinase 1 (DCLK1), a microtubule-associated protein kinase, is involved in neurogenesis, and its levels are elevated in various...
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Myeloid-derived growth factor alleviates non-alcoholic fatty liver disease alleviates in a manner involving IKKβ/NF-κB signaling
Whether bone marrow modulates systemic metabolism remains unknown. Our recent study suggested that myeloid-derived growth factor (MYDGF) improves...
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Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKβ and consequential activation of NF-κB signaling pathway
NF-κB signaling pathway is a critical link between inflammation and cancer. Emerging evidence suggested that long non-coding RNAs (lncRNAs) were...
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Inhibition of IKKβ/NF-κB signaling pathway to improve Dasatinib efficacy in suppression of cisplatin-resistant head and neck squamous cell carcinoma
Proto-oncogene tyrosine-protein kinase Src plays an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). However, the FDA-approved SRC...
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The Role of Metaflammation in the Development of Senescence-Associated Secretory Phenotype and Cognitive Dysfunction in Aging Mice
AbstractAging is accompanied by the triggering of numerous pathophysiological events, which include inflammation, cellular senescence and...
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Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells
BackgroundHucMSCs had shown promising efficacy in treating childhood diseases, but oxidative stress induced by the poor microenvironment at the site...
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LINC00942 Alleviates NaAsO2-induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p
The mechanism of arsenic-induced liver toxicity is not fully understood. This study aimed to investigate the role of LINC00942 in arsenic-induced...
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TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression,...
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CircEYA3 aggravates intervertebral disc degeneration through the miR-196a-5p/EBF1 axis and NF-κB signaling
Intervertebral disc degeneration (IDD) is a well-established cause of disability, and extensive evidence has identified the important role played by...
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HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling
Heat shock protein 90β (Hsp90β, encoded by Hsp90ab1 gene) is the most abundant proteins in the cells and contributes to variety of biological...
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miR-338-3p regulates osteoclastogenesis via targeting IKKβ gene
This study determined the effects of miR-338-3p on osteoclast (OC) differentiation and activation. The change levels of miR-338-3p in differentiated...
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Develo** PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing
RNA base editing is potential for cellular function research and genetic diseases treating. There are two main RNA base editors, REPAIR and RESCUE,...
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MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion
Tumour cells utilize multiple strategies to evade the immune system, but the underlying metabolic mechanisms remain poorly understood. The pyruvate...
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Computational analysis of 4-1BB-induced NFκB signaling suggests improvements to CAR cell design
BackgroundChimeric antigen receptor (CAR)-expressing cells are a powerful modality of adoptive cell therapy against cancer. The potency of signaling...
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Clinical investigation of lipopolysaccharide in the persistence of metabolic syndrome (MS) through the activation of GRP78-IRE1α-ASK1 signaling pathway
ObjectiveEndoplasmic reticulum stress (ERS) might play a pivotal role in the persistence of metabolic syndrome (MS). Lipopolysaccharide (LPS)...
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Aldose reductase deficiency inhibits LPS-induced M1 response in macrophages by activating autophagy
Macrophage M1 polarization mediates inflammatory responses and tissue damage. Recently, aldose reductase (AR) has been shown to play a critical role...
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Linarin Protects against Cadmium-Induced Osteoporosis Via Reducing Oxidative Stress and Inflammation and Altering RANK/RANKL/OPG Pathway
Cadmium (Cd) contamination in the environment is a major public health concern since it has been linked to osteoporosis and other bone deformities....
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MMP-9 reinforces radiation-induced delayed invasion and metastasis of neuroblastoma cells through second-signaling positive feedback with NFκB via both ERK and IKK activation
Neuroblastoma (NB) progression is branded with hematogenous metastasis and frequent relapses. Despite intensive multimodal clinical therapy,...
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MgCl2 Attenuates ox-LDL-Induced Vascular Smooth Muscle–Derived Foam Cells Pyroptosis by Downregulating the TLR4/NF-κB Signaling Pathway
Pyroptosis is a type of programmed cell death that is generally upregulated during atherosclerosis (AS). Magnesium, an important cation in the body,...
